alexa Immune responses of chronically infected adult cattle to Fasciola hepatica.


Journal of Clinical & Cellular Immunology

Author(s): Clery D, Torgerson P, Mulcahy G

Abstract Share this page

Abstract Eight adult cows, with an existing chronic Fasciola hepatica infection, were experimentally infected with 1300 metacercariae of F. hepatica, given as trickle infections, over two separate 10-day periods. Two fluke-naive heifers were similarly treated. Analysis of parasite-specific immunoglobulin isotypes IgM, IgG1, IgG2 and IgA showed IgG1 to be the dominant isotype in both chronically infected and previously naive animals. Lymphocyte proliferation assays demonstrated (a) an association between lymphocyte response and mature fluke burden in the chronically infected cattle and (b) no association between lymphocyte response and mature or immature fluke burden in naive heifers. There was no production of gamma-interferon (IFN gamma) by lymphocytes responding to adult fluke antigen. At post-mortem examination the burden of immature flukes in chronically infected and previously naive heifers was similar. This suggests that chronically infected animals may be tolerant to a moderate superinfection and that the prevailing immune mechanism in operation may be a non-protective response generated by the Th2 lymphocyte subset.
This article was published in Vet Parasitol and referenced in Journal of Clinical & Cellular Immunology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version