Author(s): Delaporte E
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Abstract The association of some immune-mediated inflammatory disease in a same patient is known. Nevertheless, this is difficult to appreciate practically for the psoriasis due to the absence of prospective study. The strongest link is with Crohn's disease and the spondyloartropathies. It is sustained by, i) genetic data obtained by genome-wide association study showing some common loci and/or genes involved in innate immunity, ii) immunologic data, these conditions sharing effector cells among which Th17 lymphocytes and inflammatory mediators (TNF-alpha, IL-1,17,23...), that explain the related efficacy of some biologics like anti-TNF-alpha, IL-12/23 antibody and others in progress and iii) environmental triggers among which bacterial infections are probably determining in the genesis of these diseases even if this is still only an hypothesis.
This article was published in Ann Dermatol Venereol
and referenced in Journal of Clinical & Cellular Immunology