Author(s): Bhalang K, Kafrawy AH, Miles DA
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Abstract BACKGROUND: Human chorionic gonadotropin (hCG) is a glycoprotein hormone comprised of two dissimilar subunits (alpha and beta) and normally is synthesized by trophoblastic tissue. Although hCG expression has been identified in a variety of neoplastic tissues, to the authors' knowledge no investigation has centered on tumors of oral origin. METHODS: Oral squamous cell carcinomas (OSCC) were studied in comparison with oral fibromas for the presence of hCGbeta using the avidin-biotin-peroxidase complex immunohistochemical technique. RESULTS: hCGbeta immunoreactivity was identified in 29 of 45 OSCC (64\%). The positively staining cells in each tumor specimen were few (range, 0.5-5\%) and were scattered throughout the tumor. When tumors were classified according to grade, it was found that hCGbeta staining was positive in 5 of 15 well differentiated OSCC (33\%), in 12 of 15 moderately differentiated OSCC (80\%), and in 12 of 15 moderately to poorly differentiated OSCC (80\%). hCGbeta immunoreactivity could not be demonstrated in any of the oral fibromas. CONCLUSIONS: The presence of hCGbeta positive tumor cells appears potentially to reflect a malignant behavior of OSCC.
This article was published in Cancer
and referenced in Journal of Clinical & Cellular Immunology