alexa Immunologic basis of cardiovascular disease in HIV-infected adults.
Infectious Diseases

Infectious Diseases

Journal of Infectious Diseases & Therapy

Author(s): Hsue PY, Deeks SG, Hunt PW

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Abstract Cardiovascular complications are more common in human immunodeficiency virus-infected individuals than in age-matched uninfected individuals. Antiretroviral therapy reduces the risk of cardiovascular complications, suggesting that viral replication directly or indirectly causes vascular disease. Long-term effective antiretroviral therapy does not fully restore vascular health, and treated adults continue to have higher-than-expected rates of disease progression. Although this excess risk during therapy is likely due to multiple factors, a growing body of evidence suggests that chronic inflammation, which persists during effective antiretroviral therapy, is directly and causally associated with vascular dysfunction and the accelerated development of atherosclerosis.
This article was published in J Infect Dis and referenced in Journal of Infectious Diseases & Therapy

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