Author(s): Mufti GJ, Figes A, Hamblin TJ, Oscier DG, Copplestone JA
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Abstract The immunoglobulin levels and autoantibody profiles of 104 patients with primary myelodysplastic syndromes (MDS), classified according to the FAB criteria, were analysed. Eight patients, four with coexistent non-Hodgkin's lymphomas, three with chronic lymphocytic leukaemia and one with a lymphoplasmacytoma, were excluded from the final analysis of immunoglobulin levels. Serum protein electrophoresis and immunoelectrophoresis revealed the presence of monoclonal gammopathy in 12 patients (12.5\%). Of the remaining 84 patients, a polyclonal rise in serum immunoglobulins was present in 27 (32\%) while a further 16 (19\%) had low immunoglobulin levels. The direct antiglobulin test was positive in eight out of 98 patients tested (8.1\%), and organ and non-organ specific autoantibodies were present in 15 out of 67 patients tested (22.3\%). Two patients had associated pernicious anaemia (PA), two hypothyroidism, and one PA with hypothyroidism. Three patients had sero-negative rheumatoid arthritis. These results demonstrate that there is a high incidence of immunological abnormalities in MDS.
This article was published in Br J Haematol
and referenced in Journal of Molecular and Genetic Medicine