alexa Immunopathogenesis of crescentic glomerulonephritis.


Journal of Nephrology & Therapeutics

Author(s): Tipping PG, Kitching AR, Cunningham MA, Holdsworth SR

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Abstract Crescentic glomerulonephritis provides an important therapeutic challenge because of its rapidly progressive course and poor outcome. Studies in animal models have elucidated some of the pivotal pathogenetic mechanisms, and human studies increasingly support the clinical relevance of these animal data. Accumulating evidence suggests that crescentic glomerulonephritis results from a complex cell-mediated nephritogenic immune response. Interruption of a number of immune and inflammatory mediators can improve the outcome of this disease.
This article was published in Curr Opin Nephrol Hypertens and referenced in Journal of Nephrology & Therapeutics

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