alexa I-MOVE multicentre case-control study 2010 11 to 2014 15: Is there within-season waning of influenza type subtype vaccine effectiveness with increasing time since vaccination?


Journal of Vaccines & Vaccination

Author(s): Kissling E, Nunes B, Robertson C, Valenciano M, Reuss A,

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Abstract Since the 2008/9 influenza season, the I-MOVE multicentre case-control study measures influenza vaccine effectiveness (VE) against medically-attended influenza-like-illness (ILI) laboratory confirmed as influenza. In 2011/12, European studies reported a decline in VE against influenza A(H3N2) within the season. Using combined I-MOVE data from 2010/11 to 2014/15 we studied the effects of time since vaccination on influenza type/subtype-specific VE. We modelled influenza type/subtype-specific VE by time since vaccination using a restricted cubic spline, controlling for potential confounders (age, sex, time of onset, chronic conditions). Over 10,000 ILI cases were included in each analysis of influenza A(H3N2), A(H1N1)pdm09 and B; with 4,759, 3,152 and 3,617 influenza positive cases respectively. VE against influenza A(H3N2) reached 50.6\% (95\% CI: 30.0-65.1) 38 days after vaccination, declined to 0\% (95\% CI: -18.1-15.2) from 111 days onwards. At day 54 VE against influenza A(H1N1)pdm09 reached 55.3\% (95\% CI: 37.9-67.9) and remained between this value and 50.3\% (95\% CI: 34.8-62.1) until season end. VE against influenza B declined from 70.7\% (95\% CI: 51.3-82.4) 44 days after vaccination to 21.4\% (95\% CI: -57.4-60.8) at season end. To assess if vaccination campaign strategies need revising more evidence on VE by time since vaccination is urgently needed. This article was published in Euro Surveill and referenced in Journal of Vaccines & Vaccination

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