alexa Impact of age of transfused blood on cerebral oxygenation in male patients with severe traumatic brain injury.
Haematology

Haematology

Journal of Blood Disorders & Transfusion

Author(s): LealNoval SR, MuozGmez M, ArellanoOrden V, MarnCaballos A, AmayaVillar R,

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Abstract OBJECTIVE: Prolonged erythrocyte storage time might reduce the efficacy of transfusion. In this study, the effects of transfusion of erythrocytes with four different storage periods (<10 days, n = 18; 10-14 days, n = 15; 15-19 days, n = 17; and >19 days, n = 16 patients) on brain tissue oxygen tension (PtiO2) in stable male patients with severe traumatic brain injury were investigated during a 24-hr follow-up period. DESIGN: Prospective, observational study. SETTING: Neurotrauma critical care unit of a university hospital. PATIENTS: Sixty-six male, nonbleeding, hemodynamically stable anemic patients (hemoglobin <95 g/L) with Glasgow Coma Scale score <9. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: PtiO2, cerebral perfusion pressure, mean arterial pressure, intracranial pressure, peripheral oxygen saturation, CO2 pressure at the end of expiration, and intracerebral temperature were recorded in all patients at baseline, immediately after the completion of transfusion, and 1, 2, 3, 4, 5, 6, 12, and 24 hrs posttransfusion. All four groups were homogeneous with respect to multiple baseline variables, except for storage time of transfused erythrocytes (p < .0001). There was a significant short-lasting (3-4 hrs) increase in PtiO2 values after transfusion of erythrocytes stored for <10 days, 10-14 days, or 15-19 days, compared with those at baseline. In contrast, no significant changes in PtiO2 were observed after transfusion of erythrocytes stored >19 days. CONCLUSIONS: Transfusion of erythrocytes increased cerebral oxygenation in patients with severe traumatic brain injury, except in those transfused with erythrocytes stored >19 days. This article was published in Crit Care Med and referenced in Journal of Blood Disorders & Transfusion

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