Author(s): Brasun J, Oldziej S, Taddei M, Kozowski H
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Abstract The studies on binding ability of longer chiral peptide nucleic acids (having four, six and eight thymines in a peptide side chain) have shown that the interactions between the nucleic base rings within a ligand molecule have a critical impact on the complex stability. Thymines inserted in the peptide side chain interact with each other as well as with peptide back-bone increasing the structural organization of the cPNA molecule. The metal ion coordination to cPNA, on the other hand, induces a very specific ligand structure, which may have a basic impact on the cPNA self-recognition processes.
This article was published in J Inorg Biochem
and referenced in Journal of Genetic Syndromes & Gene Therapy