Author(s): Reid T, Yuen A, Catolico M, Carlson RW, Reid T, Yuen A, Catolico M, Carlson RW
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Abstract Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels.
This article was published in Cancer Chemother Pharmacol
and referenced in Journal of Drug Metabolism & Toxicology