Author(s): Taylor S, Marchisio P, Vergison A, Harriague J, Hausdorff WP,
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Abstract Acute otitis media (AOM) is a leading cause of visits to physicians and of antibiotic prescriptions for young children. We systematically reviewed studies on all-cause AOM episodes and physician visits in which impact was attributed to pneumococcal conjugate vaccines, either as efficacy or effectiveness. Of 18 relevant publications found, most used the 7-valent pneumococcal conjugate vaccine (7vCRM). The efficacy of 7vCRM against all-cause AOM episodes or visits was 0\%-9\% in randomized trials and 17\%-23\% in nonrandomized trials. In observational database studies, physician visits for AOM were already declining in the 3-5 years before 7vCRM introduction (mean change, -15\%; range, +14\% to -24\%) and continued to decline afterward (mean, -19\%; range, +7\% to -48\%). This vaccine provides some protection against OM, but other factors have also contributed to the recent decline in OM incidence. Future effectiveness studies should thus use better-controlled methods to estimate the true impact of vaccination on AOM.
This article was published in Clin Infect Dis
and referenced in Otolaryngology: Open Access