alexa Impact of the serogroup A meningococcal conjugate vaccine, MenAfriVac, on carriage and herd immunity.
Psychiatry

Psychiatry

Clinical Depression

Author(s): Kristiansen PA, Diomand F, Ba AK, Sanou I, Oudraogo AS,

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Abstract BACKGROUND: The conjugate vaccine against serogroup A Neisseria meningitidis (NmA), MenAfriVac, was first introduced in mass vaccination campaigns of 1-29-year-olds in Burkina Faso in 2010. It is not known whether MenAfriVac has an impact on NmA carriage. METHODS: We conducted a repeated cross-sectional meningococcal carriage study in a representative portion of the 1-29-year-old population in 3 districts in Burkina Faso before and up to 13 months after vaccination. One district was vaccinated in September 2010, and the other 2 were vaccinated in December 2010. We analyzed 25 521 oropharyngeal samples, of which 22 093 were obtained after vaccination. RESULTS: In October-November 2010, NmA carriage prevalence in the unvaccinated districts was comparable to the baseline established in 2009, but absent in the vaccinated district. Serogroup X N. meningitidis (NmX) dominated in both vaccinated and unvaccinated districts. With 4 additional sampling campaigns performed throughout 2011 in the 3 districts, overall postvaccination meningococcal carriage prevalence was 6.95\%, with NmX dominating but declining for each campaign (from 8.66\% to 1.97\%). Compared with a baseline NmA carriage prevalence of 0.39\%, no NmA was identified after vaccination. Overall vaccination coverage in the population sampled was 89.7\%, declining over time in 1-year-olds (from 87.1\% to 26.5\%), as unvaccinated infants reached 1 year of age. NmA carriage was eliminated in both the vaccinated and unvaccinated population from 3 weeks up to 13 months after mass vaccination (P = .003). CONCLUSIONS: The disappearance of NmA carriage among both vaccinated and unvaccinated populations is consistent with a vaccine-induced herd immunity effect. This article was published in Clin Infect Dis and referenced in Clinical Depression

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