alexa Impaired myocardial radial function in asymptomatic patients with type 2 diabetes mellitus: a speckle-tracking imaging study.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Diabetes & Metabolism

Author(s): Ernande L, Rietzschel ER, Bergerot C, De Buyzere ML, Schnell F,

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Abstract BACKGROUND: Diabetic cardiomyopathy has been characterized by an early impairment of left ventricular (LV) longitudinal function as opposed to preserved LV radial function. METHODS: Conventional echocardiography and longitudinal (ε(L)) and radial (ε(R)) systolic strain assessed by speckle-tracking imaging were obtained in 114 type 2 diabetic patients and 88 age-matched controls. RESULTS: LV ejection fraction was similar in diabetic patients and controls. The presence of subclinical LV systolic dysfunction in diabetic patients was demonstrated by lower values of midwall fractional shortening (18\% ± 3\% vs 20\% ± 3\%, P = .006), ε(L) (-19\% ± 3\% vs -22\% ± 2\%, P < .001), and ε(R) (50\% ± 16\% vs 56\% ± 12\%, P = .003) compared with controls. On multivariate analysis, factors predicting strain values were diabetes (P = .001) and gender (P = .001) for ε(L) and diabetes (P = .003) for ε(R). CONCLUSION: Diabetic patients without overt heart disease display subclinical alteration of both radial and longitudinal LV systolic function even after adjustment for blood pressure, age, and body mass index. Copyright © 2010 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved. This article was published in J Am Soc Echocardiogr and referenced in Journal of Diabetes & Metabolism

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