alexa Impaired phenotype of circulating endothelial microparticles in chronic heart failure patients: Relevance to body mass index.


Clinical & Medical Biochemistry

Author(s): Berezin AE, Kremzer AA

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Abstract AIMS: The objective of the study was to investigate the relationship of circulating endothelial-derived microparticls (EMP) pattern with body mass index (BMI) in CHF patients. METHODS: The study retrospectively evolved 153 patients (86 males) who were underwent multispiral contrast-enhanced computed tomography angiography or conventional angiographic examination of coronary arteries. Flowcytometry analysis for quantifying the number of EMPs was used at baseline. RESULTS: Using C-statistics for models with CHF, BMI, and circulating biomarkers (NT-pro-BNP, OPG and adiponectin) as continuous variables we found that adding of BMI to the based model (NYHA class of CHF) improved the relative IDI by 12.5\% for increased CD31+/annexin V+ EMPs to CD62E+ EMPs ratio. When we used other model constructed on entering variables IDI appears to be improved up to 5.8\% for increased EMPs (available for NT-pro-BNP as continuous variable). Three biomarkers (NYHA class of CHF+NT-pro-BNP+OPG) and four biomarkers (NYHA class of CHF+NT-pro-BNP+OPG+adiponectin) could not significantly improve predictive model based on combination of BMI and NYHA class of CHF for increased CD31+/annexin V+ EMPs to CD62E+ EMPs ratio. CONCLUSION: We suggested that lower BMI is significant predictor for impaired phenotype of circulating EMPs in CHF patients. Copyright © 2015 Diabetes India. Published by Elsevier Ltd. All rights reserved. This article was published in Diabetes Metab Syndr and referenced in Clinical & Medical Biochemistry

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