alexa Impairment of acetylcholine synthesis in thiamine deficient rats developed by prolonged tea consumption.


Journal of Alzheimers Disease & Parkinsonism

Author(s): Ruenwongsa P, Pattanavibag S

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Abstract The synthesis of whole brain acetylcholine is reduced in thiamine deficient rats produced by prolonged administration of tea. In those rats fed a normal diet and given tea (1:50, w/v) instead of drinking water for 20 weeks, the conversion of [14C] pyruvate to [14C]acetylcholine decreased by 35\%. However, no neurological symptoms were observed. Administration of tea to rats fed a thiamine half-deficient diet for 7-8 weeks caused not only 60\% decrease in acetylcholine synthesis but also neurological symptoms. This decreased synthesis of acetylcholine is related to a decline in pyruvate dehydrogenase activity. The results suggest that prolonged administration of tea to rats cause an impairment of acetyl CoA production resulting in a deficit in acetylcholine synthesizing capacity.
This article was published in Life Sci and referenced in Journal of Alzheimers Disease & Parkinsonism

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