alexa Implementing a unified approach to family-based tests of association.
Mathematics

Mathematics

Journal of Biometrics & Biostatistics

Author(s): Laird NM, Horvath S, Xu X

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Abstract We describe a broad class of family-based association tests that are adjusted for admixture; use either dichotomous or measured phenotypes; accommodate phenotype-unknown subjects; use nuclear families, sibships or a combination of the two, permit multiple nuclear families from a single pedigree; incorporate di- or multi-allelic marker data; allow additive, dominant or recessive models; and permit adjustment for covariates and gene-by-environment interactions. The test statistic is basically the covariance between a user-specified function of the genotype and a user-specified function of the trait. The distribution of the statistic is computed using the appropriate conditional distribution of offspring genotypes that adjusts for admixture. This article was published in Genet Epidemiol and referenced in Journal of Biometrics & Biostatistics

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