alexa Improved prediction of treatment response using microarrays and existing biological knowledge.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Proteomics & Bioinformatics

Author(s): Lin SM, Devakumar J, Kibbe WA

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Abstract A desired application for microarrays in the clinic is to predict treatment response from an often diverse patient population. We present a method for analyzing microarray data that is predicated on biological pathway and function knowledge as opposed to a purely data-driven initial analysis. From an analysis perspective, this methodology takes advantage of information that is available across genes on a single array, as well as differences in those patterns across measurements. By using biological knowledge in the initial analysis, the accuracy and robustness of microarray profile classification is enhanced, especially when low numbers of samples are available. For clinical studies, particularly Phase I or I/II studies, this technique is exceptionally advantageous. This article was published in Pharmacogenomics and referenced in Journal of Proteomics & Bioinformatics

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