alexa Improvements in europium sensitized fluorimetric determination of demeclocycline and methacycline.


Medicinal Chemistry

Author(s): Mahedero MC, Bohoyo D, Salinas F, Ardila T, Airado D,

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Abstract Demeclocycline (DM) and methacycline (MT) have been determined by europium-sensitized fluorescence, using EDTA as co-ligand and cetyltrimethylammonium chloride as surfactant. The methods have been developed in slightly alkaline solutions, with the formation of a new chelate where the lanthanide ion is bound to the beta-diketone group. Calibration graphs between 0.01 and 0.1 microg mL(-1) have been obtained for DM and MT determination. Both methods have been applied to the determination of these tetracyclines in serum samples with satisfactory recovery results. This article was published in J Pharm Biomed Anal and referenced in Medicinal Chemistry

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