Author(s): Tsai IJ, Otto TD, Berriman M
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Abstract Advances in sequencing technology allow genomes to be sequenced at vastly decreased costs. However, the assembled data frequently are highly fragmented with many gaps. We present a practical approach that uses Illumina sequences to improve draft genome assemblies by aligning sequences against contig ends and performing local assemblies to produce gap-spanning contigs. The continuity of a draft genome can thus be substantially improved, often without the need to generate new data.
This article was published in Genome Biol
and referenced in Journal of Data Mining in Genomics & Proteomics