Author(s): Schwartzberg AM, Oshiro TY, Zhang JZ, Huser T, Talley CE
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Abstract We report the development of nanoprobes that exploit the surface-enhanced Raman scattering (SERS) from nonaggregated, hollow, gold nanospheres (HGNSs). The homogeneity of the HGNSs leads to a nearly 10-fold improvement in signal consistency over standard silver SERS substrates, which translates into a significant increase in sensitivity and dynamic range for the model application of pH sensing. Moreover, the small size (30-nm diameter) of these SERS-active nanoparticles represents a major step in advancing sensing technology based on SERS, making this technology more amenable to intracellular sensing.
This article was published in Anal Chem
and referenced in Journal of Nanomedicine & Nanotechnology