alexa Improving the safety of tolerance induction: chimerism and cellular co-treatment strategies applied to vascularized composite allografts.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Huang WC, Lin JY, Wallace CG, Wei FC, Liao SK

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Abstract Although vascularized composite allografts (VCAs) have been performed clinically for a variety of indications, potential complications from long-term immunosuppression and graft-versus-host disease remain important barriers to widespread applications. Recently it has been demonstrated that VCAs incorporating a vascularized long bone in a rat model provide concurrent vascularized bone marrow transplantation that, itself, functions to establish hematopoietic chimerism and donor-specific tolerance following non-myeloablative conditioning of recipients. Advances such as this, which aim to improve the safety profile of tolerance induction, will help usher in an era of wider clinical VCA application for nonlife-saving reconstructions.
This article was published in Clin Dev Immunol and referenced in Journal of Stem Cell Research & Therapy

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