alexa In search of dose-response relationships of solvent mixtures to neurobehavioural effects in paint manufacturing and painters.


Journal of Clinical Toxicology

Author(s): Seeber A, Sietmann B, Zupanic M

Abstract Share this page

Abstract Four exposure indices for the evaluation of mixtures of solvents are outlined. The hygienic effect is a relative measure depending on the limit values of the single compounds of the mixture. The cumulative lifetime exposure (CE) and the lifetime-weighted average exposure (LWAE) are approaches based on measurements of total hydrocarbons at workplaces in different time periods. Estimations of litres of solvents used per day years (l/d years) are necessary if air monitoring is not available. Five studies on neurobehavioural effects due to solvent mixtures in paint manufacturing are compared as example for dose-response relations. The best prediction of neurobehavioural dose-response relations seems to be possible using CE and LWAE for total hydrocarbon as the exposure index. Moreover, four studies on neurobehavioural effects due to solvent mixtures in paints and glues are compared. These studies indicate that the index l/d years is helpful in predicting neurobehavioural deficits. Of numerous neurobehavioural tests, the test symbol digit substitution shows the most significant dose-response relations in the studies. For symptom questionnaires these relations appear only occasionally. In principle, associations between doses of solvent mixtures in paints and neurobehavioural effects are reproducible to a limited extent.
This article was published in Food Chem Toxicol and referenced in Journal of Clinical Toxicology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version