alexa In silico Analysis of Acinetobacter baumannii Outer Membrane Protein BamA as a Potential Immunogen
Immunology

Immunology

Journal of Vaccines & Vaccination

Author(s): Ravinder Singh

Abstract Share this page

A. baumannii is an emerging nosocomial pathogen associated with health care units. Its resistance to various antibiotics gives rise to the need of vaccine development against it. Outer membrane proteins are well described vaccine candidates. The outer membrane assembly complex protein of A. baumannii, known as BamA, is an essential component of β-Barrel Assembly Machine (BAM). Vaxign analysis showed that BamA has no trans-membrane helix, adhesion probability is 0.54, no similarity to human & mouse proteome and is highly conserved (>99%) in 114 strains of A. baumannii as well as in other virulent species of Acinetobacter (78 to 94%). Multiple sequence alignment (Multalin) of BamA protein sequences from different species of Acinetobacter revealed the conserved regions and led to the identification of T cell epitopes. A number of (15) common T cell epitopes in 8 species of Acinetobacter, antigenicity (predicted score of 0.682) and outer membrane localization predict that BamA offers appropriate epitopes for immunity development against all species of Acinetobacter. Further, docking of MHC class I binding epitopes to HLA*B4405 allele and docking of epitope- HLA*B4405 complex to DM1-T cell receptor showed stable binding with low energies.

This article was published in EBSCO and referenced in Journal of Vaccines & Vaccination

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords