Author(s): Egan WJ, Zlokarnik G, Grootenhuis PD
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Abstract Predictive models for drug safety are crucial for helping to avoid costly late-stage failures. We review recent work on models for genotoxicity, liver toxicity, CYP450 inhibition and cardiotoxicity. These models have improved somewhat in recent years, and research has expanded into new frontiers, such as the prediction of liver toxicity. However, much more needs to be done.: © 2004 Elsevier Ltd . All rights reserved.
This article was published in Drug Discov Today Technol
and referenced in Drug Designing: Open Access