alexa In vitro 3D full-thickness skin-equivalent tissue model using silk and collagen biomaterials.

Journal of Bioengineering and Bioelectronics

Author(s): Bellas E, Seiberg M, Garlick J, Kaplan DL

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Abstract Current approaches to skin equivalents often only include the epidermis and dermis. Here, a full-thickness skin equivalent is described including epidermis, dermis, and hypodermis, that could serve as an in vitro model for studying skin biology or as a platform for consumer product testing. The construct is easy to handle and is maintained for >14 d while expressing physiological morphologies of the epidermis and dermis, seen by keratin 10, collagens I and IV expression. The skin equivalent produces glycerol and leptin, markers of adipose metabolism. This work serves as a foundation for understanding a few necessary factors needed to develop a stable, functional model of full-thickness skin. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
This article was published in Macromol Biosci and referenced in Journal of Bioengineering and Bioelectronics

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