alexa In vitro antimicrobial activity of silver-processed catheters for neurosurgery.
Materials Science

Materials Science

Journal of Powder Metallurgy & Mining

Author(s): Bayston R, Vera L, Mills A, Ashraf W, Stevenson O,

Abstract Share this page

Abstract OBJECTIVES: To investigate the in vitro antibacterial activity of silver-processed catheters for use in neurosurgery using clinically predictive tests. METHODS: The antimicrobial activity of a commercially available silver-processed external ventricular drain catheter was evaluated against Staphylococcus epidermidis, methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Propionibacterium acnes. Non-impregnated catheters were used as controls. Two assays were performed: (i) testing the ability of the catheter to kill 100\% of the attached bacteria (tK100); and (ii) in vitro challenge to determine the ability to prevent colonization under flow conditions. High and low inocula (10(4) and 10(7) cfu/mL) were used. Silver-processed and control catheters were examined by scanning electron microscopy and focused ion beam scanning electron microscopy; electron back-scatter and energy-dispersive X-ray analyses were used to investigate the distribution of silver within the processed catheter. RESULTS: The silver-processed catheters were not able to kill any of the bacteria tested in the tK100 assay at high inoculum. At low inoculum S. epidermidis was eradicated and some activity was seen against E. coli but without complete eradication. MRSA was also not eradicated even at low inoculum. The in vitro challenge test showed no prevention of colonization for any of the strains. Silver particles were shown to be >500 nm in size. CONCLUSIONS: The commercial silver-impregnated catheter was not able to eradicate MRSA or E. coli and while it showed activity against S. epidermidis in one assay it was unable to prevent colonization in vitro under in-flow conditions. This is consistent with clinical studies on silver-processed catheters. This article was published in J Antimicrob Chemother and referenced in Journal of Powder Metallurgy & Mining

Relevant Expert PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version