alexa In vitro antioxidant activities of methanol and aqueous extract of Annona squamosa (L.) fruit pulp.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Nandhakumar E, Indumathi P

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Abstract The present study evaluated the antioxidant activity of the fruit of Annona squamosa by means of in vitro studies involving two different solvent extracts: methanol and aqueous. The antioxidant properties of the extract were determined by scavenging 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH), lipid peroxidation (LPO), nitric oxide (NO), superoxide anion (O2(-)), hydroxyl radical (OH(•)), reducing power and total antioxidant. The results showed that, compared to aqueous extract, a methanolic fruit extract of A squamosa has a higher percentage of inhibition of DPPH radical scavenging activity (97.99\%), LPO (94.15\%), NO scavenging activity (70.96\%), O2(-) scavenging activity and OH(•) scavenging activity (78.68\% and 85.25\%, respectively), total antioxidant activity (206 μg α-tocopherol/g) and reducing power (56.0 μg of ascorbic acid/g). The results obtained in the in vitro models clearly suggest that methanol extract has higher antioxidant activity than the aqueous extract due to a higher presence of phenolic and flavonodal constituents in the methanol extract. Copyright © 2013. Published by Elsevier B.V. This article was published in J Acupunct Meridian Stud and referenced in Pharmaceutica Analytica Acta

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