alexa In vitro antitubercular and antimicrobial activities of 1-substituted quinoxaline-2,3(1H,4H)-diones.


Medicinal Chemistry

Author(s): Ramalingam P, Ganapaty S, Rao ChB

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Abstract 1-((Substituted)methyl)quinoxaline-2,3(1H,4H)-dione (2a-e) and 1-((substituted)acryloyl)quinoxaline-2,3(1H,4H)-dione (4a-c) were synthesized from quinoxaline-2,3(1H,4H)-dione 1 and evaluated for their antimicrobial activities. Results of the antitubercular screening against Mycobacterium tuberculosis H(37)Rv showed that the compounds 2b,3, and 4a were the most effective, with minimum inhibitory concentrations of 8.012, 8.561, and 8.928microg/ml, respectively. All the compounds exhibited significant antibacterial and considerable antifungal activities. Copyright 2009 Elsevier Ltd. All rights reserved. This article was published in Bioorg Med Chem Lett and referenced in Medicinal Chemistry

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