alexa In vitro Inhibition of Staphylococcus aureus Isolates by Anti-Anti-Idiotypic Antibodies to Staphylococcal Protein (SpA)
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Angel Alberto Justiz Vaillant, Patrick Eberechi Akpaka, Monica Smikle, Norma McFarlaneAnderson

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This study investigates the ability of antibodies to SpA (a protein produced by the bacterium Staphylococcus aureus) to inhibit the growth of the bacteria. Chickens immunised with SpA produced anti -SpA antibodies in their eggs (primarily the yolk). These anti-SpA antibodies were used to feed chicks, which produce antibodies that recognise the original antigen. When these antibodies were purified from their sera and included in the growth medium of the Staphylococcus aureus, there was inhibition of the bacterial growth. This indicates that these antibodies had specifically bound to the cell surface of the bacteria and prevented growth of the bacteria, i.e. the antibodies could protect against bacterial infection. The potential of such antibody in the hyper-immune egg to act as oral therapeutic agents is discussed.

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This article was published in Journal of Vaccines & Vaccination and referenced in Journal of Chromatography & Separation Techniques

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