alexa In vitro micronuclei tests to evaluate the genotoxicity of surface water under the influence of tanneries.
Nutrition

Nutrition

Vitamins & Minerals

Author(s): Lemos AO, Oliveira NC, Lemos CT

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Abstract Leather manufacturing has a high potential for environmental pollution due to hides and chemicals that are not completely absorbed during the tanning process. This study aims to investigate the mutagenic potential of surface water samples from Cadeia and Feitoria rivers (RS, Brazil) in areas influenced by tanneries and leather footwear industry. Micronucleus assays using V79 cells and human lymphocytes were used. Cells were exposed to surface water collected bimonthly from three sites for a year, totaling six samples. Significant MN induction in human lymphocytes was shown by 83\% of samples from sites FEI001 and CAD001 located downstream from the industrial area, followed by FEI004 (33\%), upstream. Only a single sample from site FEI004 showed a positive response for MN in V79 cells. Thirteen discordant and five concordant responses were found between the two in vitro tests. Mutagenic agents were found at the sites where chemical quality was worst, corroborating studies on chronic toxicity, oxidative stress and mutagenicity performed in this area. The assay using human lymphocytes was more sensitive than V79 cells to detect the contaminants from this area, showing that it is an excellent biomarker of environmental genotoxicity. Copyright © 2011 Elsevier Ltd. All rights reserved. This article was published in Toxicol In Vitro and referenced in Vitamins & Minerals

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