Author(s): Okazawa A, Maeda H, Fukusaki E, Katakura Y, Kobayashi A
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Abstract DNA aptamers that bind to hematoporphyrin IX (HPIX) were isolated using an in vitro selection technique. Most aptamers obtained after the 7th and 10th rounds contained guanine-rich sequences. Binding assay using fluorescence polarization technique and structural analysis by CD spectra revealed that the parallel guanine-quartet structure of the aptamer participates in the recognition of HPIX.
This article was published in Bioorg Med Chem Lett
and referenced in Journal of Nanomedicine & Nanotechnology