alexa In vitro uptake and release of natamycin Dex-b-PLA nanoparticles from model contact lens materials.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Clinical & Experimental Pharmacology

Author(s): Phan CM, Subbaraman L, Liu S, Gu F, Jones L

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Abstract PURPOSE: To evaluate the uptake and release of the antifungal agent natamycin encapsulated within poly(D,L-lactide)-dextran nanoparticles (Dex-b-PLA NPs) from model contact lens (CL) materials. METHODS: Six model CL materials (gel 1:poly(hydroxyethyl methacrylate, pHEMA); gel 2:85\% pHEMA: 15\% [Tris(trimethylsiloxy)silyl]-propyl methacrylate (TRIS); gel 3: 75\% pHEMA: 25\% TRIS; gel 4: 85\% N,N dimethylacrylamide (DMAA): 15\% TRIS; gel 5:75\% DMAA: 25\% TRIS; and gel 6: DMAA) were prepared using a photoinitiation procedure. The gels were incubated in: (1) natamycin dissolved in deionized (DI) water and (2) natamycin encapsulated within Dex-b-PLA NPs in dimethylsulfoxide/DI water. Natamycin release from these materials was monitored using UV-visible spectrophotometry at 304 nm over 7 d. RESULTS: Natamycin uptake by all model CL materials increased between 1 and 7 d (p < 0.001). The uptake of natamycin-NPs was higher than the uptake of the drug alone in DI water (p < 0.05). Drug release was higher in materials containing DMAA than pHEMA (p < 0.05). All gels loaded with natamycin-NPs also released more drug compared to gels soaked with natamycin in DI water (p < 0.001). After 1 h, CL materials loaded with natamycin alone released 28-82\% of the total drug release. With the exception of gel 6, this burst released was reduced to 21-54\% for CL materials loaded with natamycin-NPs. CONCLUSIONS: Model CL materials loaded with natamycin-Dex-b-PLA NPs were able to release natamycin for up to 12 h under infinite sink conditions. DMAA-TRIS materials may be more suitable for drug delivery of natamycin due to the higher drug release observed with these materials. This article was published in J Biomater Sci Polym Ed and referenced in Journal of Clinical & Experimental Pharmacology

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