alexa In vivo inhibition of polymyxin B-induced hypotension: evidence of beta-adrenergic inhibitory activity on rat mast cells.


Journal of Antimicrobial Agents

Author(s): Botana LM, Orallo F, Espinosa J, Calleja JM

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Abstract In vitro, rat mast cells show a dose-inhibition profile when stimulated with compound 48/80 in the presence of isoprenaline. Isoprenaline-induced inhibition is stereoselective at low concentrations, being greater on pleural mast cells. In vitro, polymyxin B (0.02-0.05 mg/kg) induces a marked hypotension and slow heart rate, but not tachyphylaxis. Both effects were not suppressed in the presence of isoprenaline (with short half-life in vivo), but orciprenaline does induce a clear inhibition of Polymyxin B-induced hypotension, which correlates well with heart rate.
This article was published in Gen Pharmacol and referenced in Journal of Antimicrobial Agents

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