alexa In vivo Introduced Extracellular Ubiquitin Regulates Intracellular processes
Pathology

Pathology

Journal of Molecular Histology & Medical Physiology

Author(s): Irina Modebadze

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Extracellular ubiquitin in vivo effect on regenerative liver cells and liver histoarchitectonics has been studied. Experiments were performed on mature female white rats. Partial hepatectomy was made using the modified method of Higgins and Anderson. Standard histopathological assessment of liver tissue was used. Proliferative activity of hepatocytes was analyzed by colchicine mitotic index and immunohistochemical staining on ki67. We have found that regardless of number of injections and dose of extracellular ubiquitin liver histology has not been changed, so at tissue level no effect was observed. In vivo double injection of ubiquitin significantly decreases the mitotic activity at 32 hour point after partial hepatectomy. Thus, we can conclude that in vivo injected extracellular ubiquitin inhibits proliferative activity of hepatocytes in partially hepatectomyzed rats.

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This article was published in International Journal of Biological, Biomolecular, Agricultural, Food and Biotechnological Engineering and referenced in Journal of Molecular Histology & Medical Physiology

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