alexa Inaccuracy of estimated creatinine clearance for prediction of iothalamate glomerular filtration rate.
Medicine

Medicine

Internal Medicine: Open Access

Author(s): Rolin HA rd, Hall PM, Wei R

Abstract Share this page

Abstract The clinical practice of estimating creatinine clearance (Ccr) from a patient's serum creatinine value by use of various nomograms and prediction formulas is widespread. The predictive accuracy of such Ccr estimates as substitutes for measured values of glomerular filtration rate (GFR) has not been determined. In addition, the effect of patient physical parameters on GFR prediction accuracy has not been assessed. To investigate these issues, 500 predicted Ccr values from each of four versions of the formula of Cockcroft and Gault were statistically compared with GFR values measured by sodium iothalamate clearance (Cio) in 394 human subjects representing every level of renal function. We conclude that (1) the original formula of Cockcroft and Gault is an inaccurate predictor of GFR; (2) correction of the formula for patient physical parameters does improve its accuracy for GFR prediction; (3) the best formula is not accurate enough to replace laboratory measurement of GFR; and (4) GFR prediction inaccuracy is more often associated with extremes in patient age, weight, serum creatinine, body surface area, and measured GFR but may occur for any value of each of these parameters.
This article was published in Am J Kidney Dis and referenced in Internal Medicine: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 22nd World Cardiology Conference
    December 11-12, 2017 Rome, Italy

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords