alexa Incidence and progression of diabetic retinopathy in Hong Kong Chinese with type 2 diabetes mellitus.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Diabetes & Metabolism

Author(s): Tam VH, Lam EP, Chu BC, Tse KK, Fung LM

Abstract Share this page

Abstract OBJECTIVE: We conducted a cohort study to determine the incidence and progression of diabetic retinopathy (DR) in a Chinese population with type 2 diabetes mellitus in a district hospital in Hong Kong, and to identify the risk factors associated with the development and progression of DR over 4 years. RESEARCH DESIGN AND METHODS: A total of 413 type 2 diabetic patients who followed up in our diabetic clinic and had a diabetic complication screening performed in 2001 were studied. The final analysis included 354 subjects (85.7\%) after a mean follow-up period of 4.2 years. The severity of DR was graded according to the modified Early Treatment Diabetic Retinopathy Study (ETDRS). The relationship between clinical variables and DR development and progression was determined. RESULTS: The baseline prevalence of DR was 39.2\%. On 4-year follow-up, the incidence of DR was 20.3\% (43 of 212). In those with baseline DR, 34.7\% (42 of 121) progressed by >or=2 steps in ETDRS. On multivariate analysis, a high baseline glycosylated hemoglobin (HbA(1c)) was the only predictor of DR development, while macroalbuminuria and high mean HbA(1c) predicted progression. Regression of DR, defined by a >or=2-step decrement in ETDRS, occurred in 13.2\% (12 of 91) of subjects and was associated with lower baseline HbA(1c) and absence of albuminuria. CONCLUSION: The incidence of DR in our study was similar to--but progression of DR was higher than--those reported in Caucasians. More frequent retinal screening should be offered to those with baseline DR, high HbA(1c), or albuminuria. Good glycemic control is important in order to prevent the development and progression of DR, and can lead to regression of DR. This article was published in J Diabetes Complications and referenced in Journal of Diabetes & Metabolism

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version