alexa Incidence of statin hepatotoxicity in patients with hepatitis C.
Gastroenterology

Gastroenterology

Journal of Hepatology and Gastrointestinal disorders

Author(s): Khorashadi S, Hasson NK, Cheung RC

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Abstract BACKGROUND AND AIMS: Statins are considered contraindicated in patients with chronic liver disease. Our objective was to determine the risk of developing hepatotoxicity from statin therapy in hyperlipidemic patients with hepatitis C. METHODS: Changes in liver biochemistry values within 12 months compared with baseline were determined in 3 cohorts matched for age, sex, and body mass index: (I) 166 anti-hepatitis C virus (HCV)-positive hyperlipidemic veterans who were initiated on statin therapy; (II) 332 anti-HCV-positive veterans who had not received statin therapy; and (III) 332 anti-HCV-negative hyperlipidemic veterans who were initiated on statin therapy. An increase in liver biochemistry values was defined as mild-moderate or severe as proposed in a previous study on statin hepatotoxicity in a non-hepatitis C population. RESULTS: In patients with hepatitis C, statin therapy (cohort I) was associated with a higher incidence of mild-moderate liver biochemistry value increases compared with those not on statin therapy (cohort II) (22.9\% vs 13.3\%, respectively, P = .009), but a lower incidence of severe increases (1.2\% vs 6.6\%, respectively, P = .015). Among patients started on statin therapy (cohorts I and III), the incidence of mild-moderate liver biochemistry value increases (22.9\% vs 16.3\%, respectively, P = .094), severe increases (1.2\% vs 1\%, respectively, P = .874), or discontinuation of statin therapy as a result of hepatotoxicity (21.6\% vs 9.2\%, respectively, P = .147) were similar in hepatitis C-positive and hepatitis C-negative patients. CONCLUSIONS: Statin therapy was not associated with a higher risk of severe hepatotoxicity in patients with chronic hepatitis C and appeared safe. This article was published in Clin Gastroenterol Hepatol and referenced in Journal of Hepatology and Gastrointestinal disorders

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