alexa Increase of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis.
Immunology

Immunology

Immunotherapy: Open Access

Author(s): Fujimura T, Yonekura S, Horiguchi S, Taniguchi Y, Saito A, , Fujimura T, Yonekura S, Horiguchi S, Taniguchi Y, Saito A, , Fujimura T, Yonekura S, Horiguchi S, Taniguchi Y, Saito A, , Fujimura T, Yonekura S, Horiguchi S, Taniguchi Y, Saito A,

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Abstract The aims of this study were to examine the therapeutic effects of sublingual immunotherapy (SLIT) and to identify potential biomarkers that would predict the therapeutic response in a randomized, double-blind, placebo-controlled clinical trial. The trial was carried out over two pollinosis seasons in 2007 and 2008. Carry-over therapeutic effects were analyzed in 2009. SLIT significantly ameliorated the symptoms of pollinosis during the 2008 and 2009 pollen seasons. Cry j 1-specific cytokine production in a subgroup of patients with mild disease in the SLIT group was significantly attenuated. The ratio of specific IgE to total IgE before treatment correlated with the symptom-medication score in the SLIT group in 2008. Patients with increased Cry j 1-iTreg in the SLIT group had significantly improved QOL and QOL-symptom scores. In summary, the specific IgE to total IgE ratio and upregulation of Cry j 1-iTreg are candidates for biomarker of the clinical response to SLIT. Copyright © 2011 Elsevier Inc. All rights reserved. This article was published in Clin Immunol and referenced in Immunotherapy: Open Access

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