alexa Increased prevalence of thyroid dysfunction and diabetes mellitus in Indian vitiligo patients: A case-control study.


Journal of Pigmentary Disorders

Author(s): Gopal KV, Rao GR, Kumar YH

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Abstract BACKGROUND: Though it is well-known that vitiligo is associated with other autoimmune disorders, few Indian studies have focused on the relation between vitiligo, autoimmune thyroid dysfunction and diabetes mellitus. MATERIALS AND METHODS: This case-control study included 150 new cases of vitiligo and 100 age and sex-matched controls. A complete history and thorough dermatological examination was done. Serum samples from both patients and controls were collected and assayed for triiodothyronine, thyroxine, thyroid-stimulating hormone, anti-thyroid antibodies-anti-thyroid peroxidase and anti-thyroglobulin and fasting plasma glucose. RESULTS: Thyroid hormonal profile revealed autoimmune thyroid dysfunction manifesting as hypothyroidism in 30 (20\%) vitiligo patients and two controls (2\%). Diabetes mellitus was present in 24 (16\%) vitiligo patients and five controls. Seven (4.7\%) patients had both hypothyroidism and diabetes mellitus. CONCLUSION: There is a clear association between vitiligo, autoimmune hypothyroidism and diabetes mellitus. It would be very useful to screen for thyroid dysfunction and diabetes mellitus in all patients with vitiligo.
This article was published in Indian Dermatol Online J and referenced in Journal of Pigmentary Disorders

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