alexa Increased risk of HIV acquisition among Kenyan men with human papillomavirus infection.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Smith JS, Moses S, Hudgens MG, Parker CB, Agot K,

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Abstract BACKGROUND: Few data on the effect of human papillomavirus (HPV) infection on human immunodeficiency virus (HIV) acquisition are available. METHODS: HIV-seronegative, sexually active, 18-24-year-old Kenyan men participating in a randomized trial of male circumcision provided exfoliated penile cells from 2 anatomical sites (glans/coronal sulcus and shaft) at baseline. The GP5+/6+ polymerase chain reaction assay ascertained a wide range of HPV DNA types at the baseline visit. The risk of HIV infection was estimated using Kaplan-Meier methods and hazard ratios from proportional hazards models. RESULTS: Of 2168 uncircumcised men with baseline HPV data, 1089 (50\%) were positive for HPV DNA. The cumulative incidence of HIV infection by 42 months was 5.8\% (95\% confidence interval [CI], 3.6\%-7.9\%) among men with HPV-positive glans/coronal sulcus specimens, versus 3.7\% [95\% CI, 1.8\%-5.6\%] among men with HPV-negative glans/coronal sulcus specimens (P = .01). Controlling for subsequent circumcision status, baseline herpes simplex virus type 2 serostatus, and sexual and sociodemographic risk factors, the hazard ratio for HIV infection among men with HPV-positive glans/coronal sulcus specimens was 1.8 (95\% CI, 1.1-2.9), compared with men with HPV-negative glans/coronal sulcus specimens. CONCLUSION: The results suggest an independent increased risk of HIV seroconversion among HPV-positive men. If this finding is confirmed in other studies, HPV prevention could be another tool for HIV prevention.
This article was published in J Infect Dis and referenced in Journal of AIDS & Clinical Research

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