alexa Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus.


Journal of Alzheimers Disease & Parkinsonism

Author(s): Hassani OK, Mouroux M, Fger J

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Abstract Electrophysiological records of unit activity were used to compare the effects of excitotoxic pallidal lesions and 6-hydroxydopamine-induced damage to the midbrain dopaminergic neurons on the discharge rates and patterns of the subthalamic neurons. Removal of the pallidal input induced a slight, but statistically significant, increase (19.5\%) in the discharge rate and no change in the firing pattern when compared to control animals. The rats with a dopaminergic lesion showed greater increase (105.7\%) while the firing pattern activity of the subthalamic neurons became more irregular, with burst. These results indicate that the increased activity of the subthalamic neurons following a midbrain dopaminergic lesion cannot be due solely to inhibition-disinhibition involving the striato-pallido-subthalamic pathway and induced by the striatal dopaminergic depletion.
This article was published in Neuroscience and referenced in Journal of Alzheimers Disease & Parkinsonism

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