alexa Increased susceptibility to insulin resistance associated with abdominal obesity in aging rats.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Diabetes & Metabolism

Author(s): Catalano KJ, Bergman RN, Ader M

Abstract Share this page

Abstract OBJECTIVE: Recent data have suggested that the insulin resistance observed with aging may be more related to adiposity than aging per se. We asked whether the insulin resistance observed in aged rats was comparable (both in magnitude and location) to that of fat-fed rats. RESEARCH METHODS AND PROCEDURES: We performed hyperinsulinemic (5 mU/min per kg) euglycemic clamps with tracer in conscious, 6-hour fasted young (YL), fat-fed young (YF), fat-fed old (OF), and calorically restricted old (OL) rats. RESULTS: Intraabdominal fat measurements showed that OF and YF rats were more obese than YL (pOF>YL). Caloric restriction not only prevented age-related obesity but also reduced the ratio of intraabdominal fat to lean body mass (LBM) compared with YL (OL: 0.59+/-0.05 vs. YL: 1.07+/-0.04; p=0.017). Despite similar incremental insulin, YF and OF rats required 40\% less infused glucose to maintain euglycemia than YL and OL rats (p<0.001). Insulin-stimulated glucose uptake (Si(Rd): DeltaRd/(DeltaInsulin x Glucose(SS)) was impaired in OF rats (OF: 14.03+/-1.79 vs. YL: 23.08+/-1.87x10(3) dL/min x kg LBM per pM; p=0.004) and improved in OL rats (29.41+/-1.84x10(3) dL/min x kg LBM per pM; p=0.031) compared with YL. Despite greater obesity, YF rats did not exhibit lower SiRd compared with OF rats (p=0.58). In contrast, the ability of insulin to suppress endogenous glucose production (EGP; Si(EGP): DeltaEGP/(DeltaInsulin x GlucoseSS) was not impaired in OF rats (OF vs. YL; p=0.61) but was markedly impaired in YF rats by approximately 75\% (1.72+/-0.66x10(3) dL/min x kg per pM; p=0.013). Surprisingly, separate regression analysis for old and young animals revealed that old rats exhibited a significantly steeper regression between Si (Rd and EGP) and adiposity than young rats (p<0.05). Thus, older rats showed a proportionately greater decrement in insulin sensitivity with an equivalent increase in adiposity. DISCUSSION: These data suggest that, in rodents, youth affords significant protection against obesity-induced insulin resistance. This article was published in Obes Res and referenced in Journal of Diabetes & Metabolism

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords