alexa Individual dopamine midbrain neurons: functional diversity and flexibility in health and disease.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Steroids & Hormonal Science

Author(s): Liss B, Roeper J

Abstract Share this page

Abstract Dopaminergic midbrain neurons are involved in many important brain functions including motor control, as well as emotive and cognitive tasks. They also play critical roles in major disorders likes Parkinson disease, schizophrenia, drug abuse and attention-deficit hyperactivity disorder. This bewildering diversity of distinct dopaminergic functions appears to be in contrast to the routinely assumed functional homogeneity of dopaminergic midbrain neurons at the level of individual cells. If they indeed would conform to a single stereotypical phenotype, the functional diversity of dopaminergic neurons would be predominantly mediated by their involvement in anatomically distinct subcortical and cortical neuronal networks and their distinct postsynaptic targets. However, there is increasing evidence for functional diversity as well as plasticity within the population of dopaminergic midbrain neurons. In addition, dopaminergic midbrain neurons are also not homogeneously affected by disease processes, but instead show large differences in their relative vulnerability, especially their susceptibility to cell death in Parkinson disease. Here, we review recent progress in understanding diversity and flexibility of individual dopaminergic midbrain neurons at molecular and functional levels. This article was published in Brain Res Rev and referenced in Journal of Steroids & Hormonal Science

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version