alexa Indomethacin in streptozocin-induced nephrogenic diabetes insipidus.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Diabetes & Metabolism

Author(s): Delaney V, de Pertuz Y, Nixon D, Bourke E

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Abstract A 14-year-old female patient with metastatic carcinoid developed streptozocin-induced glomerular, proximal, and distal tubular dysfunction. The latter was in the form of nephrogenic diabetes insipidus, with urine volumes in excess of 11 L/24 h. The prostaglandin synthetase inhibitor, indomethacin, rapidly corrected the polyuria both initially and on rechallenge, independent of change in glomerular filtration rate.
This article was published in Am J Kidney Dis and referenced in Journal of Diabetes & Metabolism

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