alexa Induction of changes in the secondary structure of globular proteins by a hydrophobic surface.
Materials Science

Materials Science

Journal of Nanomedicine & Nanotechnology

Author(s): Wu H, Fan Y, Sheng J, Sui SF

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Abstract Circular dichroism, ellipsometry and radiolabeling techniques were employed to study the induction of changes in the secondary structure of BSA, myoglobin and cytochrome C by a hydrophobic surface. The results showed that adsorbed protein molecules lose their ordered native structure in the initial stage of adsorption and the structure appears to be a random or disordered conformation. Protein molecules adsorbed in later stages adopt a more ordered secondary structure (alpha helix and beta structure). The changes of secondary structure of globular proteins induced by a hydrophobic surface can be explained by the steric interaction between adsorbed proteins as well as by hydrophobic interactions during the adsorption process. In addition, there is obviously an intermediate stage in which the protein molecules are mainly in the beta structure, indicating that for certain proteins, the beta structure may be a more stable secondary structure than alpha helix on the hydrophobic surface.
This article was published in Eur Biophys J and referenced in Journal of Nanomedicine & Nanotechnology

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