alexa Induction of chromosomal aberrations in fish Boleophthalmus dissumieri after exposure in vivo to mitomycin C and heavy metals mercury, selenium and chromium.
Agri and Aquaculture

Agri and Aquaculture

Fisheries and Aquaculture Journal

Author(s): Krishnaja AP, Rege MS

Abstract Share this page

Abstract The possibilities were explored of using fish as a cytogenetic model in vivo for the detection of potential mutagens. Boleophthalmus dussumieri (2n = 46, fairly large acrocentric chromosomes), an edible mud-skipper and a widely occurring Goby along the Bombay coast, was chosen as the test species after screening 20 species of fish locally available. I.m. injections of mitomycin C in the dose range of 0.5-2.0 mg/kg body weight resulted in a significant increase in the frequency of aberrations per metaphase compared with the control. A dose-response effect was also evident. The types of aberration observed included chromatid and isochromatid breaks, fragments, rings, exchanges and unclassified markers. A significant increase in the number of gaps was also observed. Clastogenic effects of metals such as Hg, Se and Cr in the form of phenyl mercuric acetate, selenium dioxide and sodium dichromate following direct (i.m. injections) and indirect (dissolved in the aquarial water) exposures were studied. A marked enhancement was noticed in the aberration frequency at most of the dose levels tested. Spontaneous chromosomal aberrations in this species were rather rare and occurred at a rate close to zero. If developed along proper lines, fish could be a useful biological model for studying the teratogenic, carcinogenic and mutagenic effects of environmental chemicals.
This article was published in Mutat Res and referenced in Fisheries and Aquaculture Journal

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version