alexa Induction of immunomodulating cytokines by a new polysaccharide-peptide complex from culture mycelia of Lentinus edodes.
Oncology

Oncology

Journal of Integrative Oncology

Author(s): Liu M, Li J, Kong F, Lin J, Gao Y, Liu M, Li J, Kong F, Lin J, Gao Y, Liu M, Li J, Kong F, Lin J, Gao Y, Liu M, Li J, Kong F, Lin J, Gao Y

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Abstract The immunomodulating effect of a new polysaccharide-peptide complex from culture mycelia of Lentinus edodes (LE) was studied for elucidation of the mechanism of augmentation of cell-mediated immunity. RNA samples were isolated from the untreated and treated murine splenocytes and human peripheral blood mononuclear cells. RT-PCR was used to analyze the cytokine gene expression and bioassay was used to analyze the cytokine production. By administration of LE, the expression levels of IL-2 and TNF-alpha genes were augmented in the treated murine spleen mononuclear cells and human peripheral blood mononuclear cells. The production of IL-2 were augmented in the treated murine spleen mononuclear cells, and the production of TNF-alpha were augmented in the treated murine peritoneal exudate macrophages. The production of IL-2 and TNF-alpha were augmented in the treated human peripheral blood mononuclear cells. These results suggest that LE may induce Th immune responses.
This article was published in Immunopharmacology and referenced in Journal of Integrative Oncology

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