alexa Inefficacy of high-dose transdermal fentanyl in a patient with neuropathic pain, a case report.
General Science

General Science

Journal of Forensic Research

Author(s): Bleeker CP, Bremer RC, Dongelmans DA, van Dongen RT, Crul BJ, Bleeker CP, Bremer RC, Dongelmans DA, van Dongen RT, Crul BJ

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Abstract Pain partially responsive to opioids can lead to rapid escalating dosages due to tolerance development. In this report the case of a 58-year-old female with neuropathic pain using increasing transdermal (TTS) fentanyl dosages to a maximum dose of 3400 microg/h resulting in fentanyl plasma levels of 173 ng/ml is described. For pain relief an epidural infusion at the level T1-2 with bupivacaine was started. Immediate pain relief was accompanied by short lasting respiratory depression and drowsiness. Copyright 2001 European Federation of Chapters of the International Association for the study of Pain. This article was published in Eur J Pain and referenced in Journal of Forensic Research

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