Author(s): Constantinides P, Whyman J
When the coagulation-promoting materials Russell viper venom, rat serum, red cell extract or ε-aminocaproic acid were given to atherosclerotic rabbits in combination with viosterol and adrenalin, they induced tiny infarct-like myocardial necroses (some accompanied by coronary arteriolar thromboses) in a small percentage of the animals. Similar lesions were produced in a few atherosclerotic rabbits by the combination of phosphatidylethanolamine, brain thromboplastin or atheroma homogenate with adrenalin (without viosterol). Given alone, the coagulation-promoting materials failed to produce arterial thromboses and infarcts anywhere, with the exception of brain thromboplastin and Russell viper venom. Both these agents caused pulmonary arterial thromboses with infarcts, and in addition, Russell viper venom (given intraperitoneally or subcutaneously) produced large arterial thromboses with classical infarcts in the kidneys, thus exhibiting the ability to overcome the lung barrier and to elicit effective hypercoagulability of the blood in the greater circulation. No infarct-like necroses were induced by either viosterol or adrenalin alone, but acute heart failure with lethal lung edema was produced in atherosclerotic rabbits by only 1/8th of the intravenous adrenalin dose that was required to produce the same effect in normal animals.