alexa Infarction and infarctoid necrosis in atherosclerotic rabbits
Clinical Sciences

Clinical Sciences

Cardiovascular Pharmacology: Open Access

Author(s): Constantinides P, Whyman J

Abstract Share this page

When the coagulation-promoting materials Russell viper venom, rat serum, red cell extract or ε-aminocaproic acid were given to atherosclerotic rabbits in combination with viosterol and adrenalin, they induced tiny infarct-like myocardial necroses (some accompanied by coronary arteriolar thromboses) in a small percentage of the animals. Similar lesions were produced in a few atherosclerotic rabbits by the combination of phosphatidylethanolamine, brain thromboplastin or atheroma homogenate with adrenalin (without viosterol). Given alone, the coagulation-promoting materials failed to produce arterial thromboses and infarcts anywhere, with the exception of brain thromboplastin and Russell viper venom. Both these agents caused pulmonary arterial thromboses with infarcts, and in addition, Russell viper venom (given intraperitoneally or subcutaneously) produced large arterial thromboses with classical infarcts in the kidneys, thus exhibiting the ability to overcome the lung barrier and to elicit effective hypercoagulability of the blood in the greater circulation. No infarct-like necroses were induced by either viosterol or adrenalin alone, but acute heart failure with lethal lung edema was produced in atherosclerotic rabbits by only 1/8th of the intravenous adrenalin dose that was required to produce the same effect in normal animals.

  • To read the full article Visit
  • Open Access
This article was published in J Atheroscler Res and referenced in Cardiovascular Pharmacology: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords