alexa Inflammatory blockade restores adult hippocampal neurogenesis.
Engineering

Engineering

International Journal of Advance Innovations, Thoughts & Ideas

Author(s): Monje ML, Toda H, Palmer TD

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Abstract Cranial radiation therapy causes a progressive decline in cognitive function that is linked to impaired neurogenesis. Chronic inflammation accompanies radiation injury, suggesting that inflammatory processes may contribute to neural stem cell dysfunction. Here, we show that neuroinflammation alone inhibits neurogenesis and that inflammatory blockade with indomethacin, a common nonsteroidal anti-inflammatory drug, restores neurogenesis after endotoxin-induced inflammation and augments neurogenesis after cranial irradiation. This article was published in Science and referenced in International Journal of Advance Innovations, Thoughts & Ideas

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